Details

Autor(en) / Beteiligte

• Gudkov, S. V.
• Garmash, S. A.
• Shtarkman, I. N.
• Chernikov, A. V.
• Karp, O. E.
• Bruskov, V. I.

Titel

Long-lived protein radicals induced by X-ray irradiation are the source of reactive oxygen species in aqueous medium

Ist Teil von

• Doklady. Biochemistry and biophysics, 2010-02, Vol.430 (1), p.1-4

Ort / Verlag

Dordrecht: SP MAIK Nauka/Interperiodica

Erscheinungsjahr

2010

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• A considerable proportion of biopolymer damages in the cell induced by ionizing radiation are produced by reactive oxygen species (ROS) generated during water radiolysis. It was established that, among all biomacromolecules, proteins are the key and most sensitive target of the hydroxyl radical (OH[dot]), the most reactive ROS. In addition, the content of proteins in cells (approximately 15%) is higher than the content of other biopolymers. It is believed that protein oxidation by free radicals underlies cell aging and induces a number of human diseases. However, the role of ionizing radiation induced oxidative damages of proteins in the development of oxidative stress in cells has been insufficiently studied.