Details

Autor(en) / Beteiligte

• Dinh Thanh, Nguyen
• Son Hai, Do
• Thi Ngoc Bich, Vu
• Thi Thu Hien, Pham
• Thi Ky Duyen, Nguyen
• Thi Mai, Nguyen
• Thi Dung, Tran
• Thi Kim Van, Hoàng
• Ngoc Toan, Vu
• Huy, Nguyen Hung
• Thi Thanh Van, Tran
• Ngoc Toan, Duong
• Hai Dang, Le

Titel

Synthesis and structure of some substituted 2-amino-4-aryl-7-propargyloxy-4H-chromene-3-carbonitriles

Ist Teil von

• Synthetic communications, 2019-01, Vol.49 (1), p.102-117

Ort / Verlag

Philadelphia: Taylor & Francis

Erscheinungsjahr

2019

Quelle

Taylor & Francis

Beschreibungen/Notizen

• A series of 2-amino-7-hydroxy-4H-chromene-3-carbonitriles 4a-l were synthesized through three-component reaction using sodium carbonate as a catalyst. The reaction was carried out in 96% ethanol-water medium (1:20 ratio in volume). Propargyl ether compounds 5a-l of these chromene-3-carbonitriles were successfully synthesized from corresponding hydroxyl chromene derivatives by reaction with propargyl bromide. Two different procedures were applied in this process: the procedure that used potassium carbonate in dried acetone and the procedure that used sodium hydride in dried DMF. The latter gave the ethers 5a-l in higher yields. The single-crystal X-ray structure of propargyl ether 5g has been recorded.