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Influence of PDLA nanoparticles size on drug release and interaction with cells
Journal of biomedical materials research. Part A, 2019-03, Vol.107 (3), p.482-493
Cartaxo, Ana Luísa
Costa‐Pinto, Ana R.
Martins, Albino
Faria, Susana
Gonçalves, Virgínia M. F.
Tiritan, Maria Elizabeth
Ferreira, Helena
Neves, Nuno M.
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Cartaxo, Ana Luísa
Costa‐Pinto, Ana R.
Martins, Albino
Faria, Susana
Gonçalves, Virgínia M. F.
Tiritan, Maria Elizabeth
Ferreira, Helena
Neves, Nuno M.
Titel
Influence of PDLA nanoparticles size on drug release and interaction with cells
Ist Teil von
Journal of biomedical materials research. Part A, 2019-03, Vol.107 (3), p.482-493
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2019
Quelle
Wiley-Blackwell Full Collection
Beschreibungen/Notizen
Polymeric nanoparticles (NPs) are strong candidates for the development of systemic and targeted drug delivery applications. Their size is a determinant property since it defines the NP–cell interactions, drug loading capacity, and release kinetics. Herein, poly(d,l‐lactic acid) (PDLA) NPs were produced by the nanoprecipitation method, in which the influence of type and concentration of surfactant as well as PDLA concentration were assessed. The adjustment of these parameters allowed the successful production of NPs with defined medium sizes, ranging from 80 to 460 nm. The surface charge of the different NPs populations was consistently negative. Prednisolone was effectively entrapped and released from NPs with statistically different medium sizes (i.e., 80 or 120 nm). Release profiles indicate that these systems were able to deliver appropriate amounts of drug with potential applicability in the treatment of inflammatory conditions. Both NPs populations were cytocompatible with human endothelial and fibroblastic cells, in the range of concentrations tested (0.187–0.784 mg/mL). However, confocal microscopy revealed that within the range of sizes tested in our experiments, NPs presenting a medium size of 120 nm were able to be internalized in endothelial cells. In summary, this study demonstrates the optimization of the processing conditions to obtain PDLA NPs with narrow size ranges, and with promising performance for the treatment of inflammatory diseases. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 482–493, 2019.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.36563
Titel-ID: cdi_proquest_journals_2172470893
Format
–
Schlagworte
Cell interactions
,
cell internalization
,
Cell Line
,
Confocal microscopy
,
cytocompatibility
,
Drug Carriers - chemistry
,
Drug Carriers - pharmacokinetics
,
Drug Carriers - pharmacology
,
Drug delivery
,
Drug delivery systems
,
Endothelial cells
,
Endothelial Cells - cytology
,
Endothelial Cells - metabolism
,
Fibroblasts - cytology
,
Fibroblasts - metabolism
,
Humans
,
Inflammatory diseases
,
Kinetics
,
Lactic acid
,
Medical treatment
,
Microscopy
,
Nanoparticles
,
Nanoparticles - chemistry
,
Optimization
,
Particle Size
,
PDLA nanoparticles
,
Polyesters - chemistry
,
Polyesters - pharmacokinetics
,
Polyesters - pharmacology
,
Populations
,
Prednisolone
,
Prednisolone - chemistry
,
Prednisolone - pharmacokinetics
,
Prednisolone - pharmacology
,
size distribution
,
Surface charge
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