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The aim of this paper is to discuss the existence of mild solutions for a class of semilinear stochastic partial differential equation with nonlocal initial conditions and noncompact semigroups in a real separable Hilbert space. Combined with the theory of stochastic analysis and operator semigroups, a generalized Darbo’s fixed point theorem and a new estimation technique of the measure of noncompactness, we obtained the existence of mild solutions under the situation that the nonlinear term and nonlocal function satisfy some appropriate local growth conditions and a noncompactness measure condition. In addition, the condition of uniformly continuity of the nonlinearity is not required and also the strong restriction on the constants in the condition of noncompactness measure is completely deleted in this paper. An example to illustrate the feasibility of the main results is also given.