Food & function, 2019-01, Vol.1 (1), p.26-32
2019
Details
- Autor(en) / Beteiligte
- Titel
- Dietary (−)-epicatechin affects NF-κB activation and NADPH oxidases in the kidney cortex of high-fructose-fed rats
- Ist Teil von
- Food & function, 2019-01, Vol.1 (1), p.26-32
- Ort / Verlag
- England: Royal Society of Chemistry
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Inflammation involves the activation of redox-sensitive transcription factors, e.g. , nuclear factor κB (NF-κB). Administration of (−)-epicatechin to high-fructose-fed rats prevented NF-κB activation and up-regulation of the NADPH oxidase 4 (NOX4) in the kidney cortex. These results add mechanistic insights into the action of (−)-epicatechin diminishing inflammatory responses. The activation of NF-κB and NOXs in rat kidney is attenuated by dietary supplementation of (−)-epicatechin.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2042-6496eISSN: 2042-650XDOI: 10.1039/c8fo02230eTitel-ID: cdi_proquest_journals_2169385280
- Format
- –
- Schlagworte
- Animals, Catechin - metabolism, Diet, Epicatechin, Fructose, Fructose - metabolism, Inflammation, Kidney Cortex - enzymology, Kidney Cortex - metabolism, Kidneys, Male, NAD(P)H oxidase, NADPH Oxidase 1 - genetics, NADPH Oxidase 1 - metabolism, NADPH Oxidase 2 - genetics, NADPH Oxidase 2 - metabolism, NADPH Oxidase 4 - genetics, NADPH Oxidase 4 - metabolism, NF-kappa B - genetics, NF-kappa B - metabolism, NF-κB protein, NOX4 protein, Rats, Rats, Sprague-Dawley, Renal cortex, Rodents, Signal Transduction, Toll-Like Receptor 4 - genetics, Toll-Like Receptor 4 - metabolism, Transcription activation, Transcription factors