Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes
Ist Teil von
Diabetes (New York, N.Y.), 2003-01, Vol.52 (1), p.145-148
Ort / Verlag
Alexandria, VA: American Diabetes Association
Erscheinungsjahr
2003
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Apolipoprotein-E Influences Aspects of Intellectual Ability in Type 1 Diabetes
Stewart C. Ferguson 1 ,
Ian J. Deary 2 ,
Julie C. Evans 3 ,
Sian Ellard 3 ,
Andrew T. Hattersley 3 and
Brian M. Frier 1
1 Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, U.K.
2 Department of Psychology, University of Edinburgh, Edinburgh, Scotland, U.K.
3 Centre for Molecular Genetics, Exeter University, Exeter, England, U.K.
Abstract
The ε4 allele of the apolipoprotein-E (APOE) gene is associated with poor outcome following various cerebral insults. The
relationship between APOE genotype and cognitive function in patients with type 1 diabetes is unknown. In a cross-sectional
study of 96 people with type 1 diabetes, subjects were APOE genotyped, previous exposure to severe hypoglycemia was estimated
by questionnaire, and cognition was assessed by neuropsychological testing. Cognitive abilities were compared using multivariate
general linear modeling (multiple analysis of covariance, MANCOVA) in those with ( n = 21) and without ( n = 75) the APOE ε4 allele. APOE ε4 selectively influenced cognitive ability in a sex-specific manner (F = 2.3, P = 0.044, Eta 2 = 0.15); women with APOE ε4 performed less well on tests of current, nonverbal intellectual ability (Wechsler Adult Intelligence
Scale-Revised performance test score, P = 0.001, Eta 2 0.26) and frontal lobe and executive function (Borkowski verbal fluency, P = 0.016, Eta 2 = 0.15). Previous exposure to severe hypoglycemia did not interact with APOE ε4 to produce cognitive disadvantage. The APOE
ε4 genotype is associated with specific cognitive disadvantage in young women with type 1 diabetes. APOE ε4 is unlikely to
mediate susceptibility to hypoglycemia-induced cognitive disadvantage.
Footnotes
Address correspondence and reprint requests to Prof. Ian J. Deary, Department of Psychology, University of Edinburgh, 7 George
Square, Edinburgh, EH8 9JZ, Scotland. E-mail: i.deary{at}ed.ac.uk .
Received for publication 13 May 2002 and accepted in revised form 7 October 2002.
APOE, apolipoprotein-E; MANCOVA, multiple analysis of covariance; NART, National Adult Reading Test; WAIS-R, Wechsler Adult
Intelligence Scale-Revised.
DIABETES