Details

Autor(en) / Beteiligte

• Lee, Byung Chul
• Kim, Dong Hyun
• Lee, Jae Hak
• Sung, Hyun Ju

Titel

sup 99m^Tc(CO)^sub 3^-15-[N-(Acetyloxy)-2-picolylamino] pentadecanoic Acid: A Potential Radiotracer for Evaluation of Fatty Acid Metabolism

Ist Teil von

• Bioconjugate chemistry, 2007-07, Vol.18 (4), p.1332

Ort / Verlag

Washington: American Chemical Society

Erscheinungsjahr

2007

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• ...pentadecanoic acid (1a) was prepared by incorporating ... into 15-[N-(hydroxycarbonylmethyl)-2-picolylamino]pentadecanoic acid (2a). The overall radiochemical yield of 1a after HPLC purification was 60-63%. Radiotracer 1a was found to be chemically stable when incubated in human plasma for 4 h at 37 ... C. Tissue distribution studies showed that high radioactivity accumulated in the heart with rapid clearance. The maximum heart-to-blood uptake ratio was 1.87 at 5 mm after a tail-vein injection. Radioactive metabolites were analyzed in urine samples of mice and corresponded to a 9.3:1 ratio of ... pentanoic acid (1b) to ...propionic acid (1c), indicating that 1a is mainly metabolized to 1b via β-oxidation in the body. These results suggest that 1a is a promising radiotracer for evaluation of fatty acid metabolism in myocardium. (ProQuest-CSA LLC: ... denotes formulae/symbols omitted.)