Details

Autor(en) / Beteiligte

• Fan, Yi‐Lei
• Huang, Zhong‐Ping
• Liu, Min

Titel

Design, Synthesis and Antitumor Activities of 1,2,3‐triazole‐diethylene Glycol Tethered Isatin Dimers

Ist Teil von

• Journal of heterocyclic chemistry, 2018-12, Vol.55 (12), p.2990-2995

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• A series of novel 1,2,3‐triazole‐diethylene glycol tethered isatin dimers were designed, synthesized, and screened for their in vitro antitumor activities in this paper. All dimers showed promising activities against the tested HepG2, Hela, A549, DU145, SKOV3, MCF‐7, and doxorubicin‐resistant MCF‐7 human cancer cell lines. The most active dimer 7g was >1.55 folds more potent than etoposide against all tested cell lines, warrant further investigation.