Details

Autor(en) / Beteiligte

• Schächinger, Volker
• Erbs, Sandra
• Elsässer, Albrecht
• Haberbosch, Werner
• Hambrecht, Rainer
• Hölschermann, Hans
• Yu, Jiangtao
• Corti, Roberto
• Mathey, Detlef G
• Hamm, Christian W
• Süselbeck, Tim
• Werner, Nikos
• Haase, Jürgen
• Neuzner, Jörg
• Germing, Alfried
• Mark, Bernd
• Assmus, Birgit
• Tonn, Torsten
• Dimmeler, Stefanie
• Zeiher, Andreas M

Titel

Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial

Ist Teil von

• European heart journal, 2006-12, Vol.27 (23), p.2775-2783

Ort / Verlag

England: Oxford Publishing Limited (England)

Erscheinungsjahr

2006

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• To investigate the clinical outcome after intracoronary administration of autologous progenitor cells in patients with acute myocardial infarction (AMI). Using a double-blind, placebo-controlled multicentre trial design, we randomized 204 patients with successfully reperfused AMI to receive intracoronary infusion of bone-marrow-derived progenitor cells (BMCs) or placebo medium into the infarct artery 3-7 days after successful infarct reperfusion therapy. At 12 months, the pre-specified cumulative endpoint of death, myocardial infarction, or necessity for revascularization was significantly reduced in the BMC group compared with placebo (P=0.009). Likewise, the combined endpoint death, recurrence of myocardial infarction, and rehospitalization for heart failure was significantly (P=0.006) reduced in patients receiving intracoronary BMC administration. Intracoronary administration of BMC remained a significant predictor of a favourable clinical outcome by Cox regression analysis, adjusting for classical predictors of poor outcome after AMI. Intracoronary administration of BMCs is associated with a significant reduction of the occurrence of major adverse cardiovascular events after AMI. Large-scale studies are warranted to confirm the effects of BMC administration on mortality and morbidity in patients with AMIs.