Details

Autor(en) / Beteiligte

• Younan, Soraia
• Sakita, Gabriel Zanuto
• Coluna, João Gabriel Younan
• Rufino, Marcos Natal
• Keller, Rogéria
• Bremer‐Neto, Hermann

Titel

Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial

Ist Teil von

• Journal of the science of food and agriculture, 2019-01, Vol.99 (1), p.183-190

Ort / Verlag

Chichester, UK: John Wiley & Sons, Ltd

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• BACKGROUND The present study aimed to evaluate the nutritional, physiological and biochemical effects of dietary supplementation of an association of probiotic bacteria in rats intoxicated with chromium (VI). Ninety‐six male rats, recently weaned, were randomly divided into eight groups (n = 12): Control, DK12, DK24 and DK36 (0, 0.12, 0.24 and 0.36 g kg−1 of K2Cr2O7 incorporated in the basal feed, respectively) and groups Prob, DK12 + Prob, DK24 + Prob and DK36 + Prob received a progressive dose of 0, 0.12, 0.24 and 0.36 g kg−1 of K2Cr2O7 incorporated in the basal feed and supplemented with 0.02 g kg−1 of an association of probiotic bacteria (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum). RESULTS After 90 days, we observed significant (P < 0.05) and dose‐dependent alterations from incorporation of increasing doses of chromium (VI) related to nutritional, physiological and biochemical parameters. These changes were attenuated (P < 0.05) with probiotic supplementation. CONCLUSION Supplementation with probiotics in the diet beneficially modified the nutritional and physiological parameters, as well as hepatic, renal, glycemic and lipid profiles, of animals intoxicated with increasing doses of K2Cr2O7. © 2018 Society of Chemical Industry