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Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial
Journal of the science of food and agriculture, 2019-01, Vol.99 (1), p.183-190
Younan, Soraia
Sakita, Gabriel Zanuto
Coluna, João Gabriel Younan
Rufino, Marcos Natal
Keller, Rogéria
Bremer‐Neto, Hermann
2019
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Younan, Soraia
Sakita, Gabriel Zanuto
Coluna, João Gabriel Younan
Rufino, Marcos Natal
Keller, Rogéria
Bremer‐Neto, Hermann
Titel
Probiotic mitigates the toxic effects of potassium dichromate in a preclinical study: a randomized controlled trial
Ist Teil von
Journal of the science of food and agriculture, 2019-01, Vol.99 (1), p.183-190
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2019
Quelle
MEDLINE
Beschreibungen/Notizen
BACKGROUND The present study aimed to evaluate the nutritional, physiological and biochemical effects of dietary supplementation of an association of probiotic bacteria in rats intoxicated with chromium (VI). Ninety‐six male rats, recently weaned, were randomly divided into eight groups (n = 12): Control, DK12, DK24 and DK36 (0, 0.12, 0.24 and 0.36 g kg−1 of K2Cr2O7 incorporated in the basal feed, respectively) and groups Prob, DK12 + Prob, DK24 + Prob and DK36 + Prob received a progressive dose of 0, 0.12, 0.24 and 0.36 g kg−1 of K2Cr2O7 incorporated in the basal feed and supplemented with 0.02 g kg−1 of an association of probiotic bacteria (Lactobacillus acidophilus, Enterococcus faecium, Bifidobacterium thermophilum and Bifidobacterium longum). RESULTS After 90 days, we observed significant (P < 0.05) and dose‐dependent alterations from incorporation of increasing doses of chromium (VI) related to nutritional, physiological and biochemical parameters. These changes were attenuated (P < 0.05) with probiotic supplementation. CONCLUSION Supplementation with probiotics in the diet beneficially modified the nutritional and physiological parameters, as well as hepatic, renal, glycemic and lipid profiles, of animals intoxicated with increasing doses of K2Cr2O7. © 2018 Society of Chemical Industry
Sprache
Englisch
Identifikatoren
ISSN: 0022-5142
eISSN: 1097-0010
DOI: 10.1002/jsfa.9159
Titel-ID: cdi_proquest_journals_2140806555
Format
–
Schlagworte
Animals
,
Bacteria
,
Chromium
,
Cr (VI)
,
Diet
,
Drug Evaluation, Preclinical
,
Feed additives
,
functional foodsglycemic profile
,
Heavy Metal Poisoning - drug therapy
,
Heavy Metal Poisoning - etiology
,
Heavy Metal Poisoning - pathology
,
Humans
,
intoxication
,
Kidney - drug effects
,
Kidney - pathology
,
Lactobacillaceae - physiology
,
Lactobacillus acidophilus
,
lipid profile
,
Lipids
,
Liver - drug effects
,
Liver - pathology
,
Male
,
nutritional parameters
,
Organic chemistry
,
Parameter modification
,
Physiological effects
,
Physiology
,
Potassium
,
Potassium dichromate
,
Potassium Dichromate - toxicity
,
Probiotics
,
Probiotics - administration & dosage
,
Probiotics - analysis
,
Random Allocation
,
Rats
,
Rats, Wistar
,
Toxicity
,
Yogurt
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