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The Impact of Preoperative Immunomodulation on Pouch-Related Septic Complications After Ileal Pouch-Anal Anastomosis
Ist Teil von
Diseases of the colon & rectum, 2007-07, Vol.50 (7), p.943-951
Ort / Verlag
Secaucus, NJ: The ASCRS
Erscheinungsjahr
2007
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
PURPOSE:
METHODS:
RESULTS:There were 445 patients (206 females; 46.4 percent). Median age was 36 (interquartile range, 27-46) years. Median follow-up period was 52 (interquartile range, 26-86) months. Complete data were available for 335 patients. Early sepsis was seen in 58 patients (17.3 percent). Another 22 patients (6.5 percent) developed late sepsis. On multivariate analysis, only steroid use remained predictive of higher rates of early sepsis (odds ratio, 1.81; 95 percent confidence interval, 1.02-3.45; P = 0.002). Likewise on multivariate analysis, both male gender (odds ratio, 0.24; 95 percent confidence interval, 0.09-0.71; P = 0.007) and 5-aminosalicylic-acid use (odds ratio, 0.22; 95 percent confidence interval, 0.08-0.76; P = 0.023) remained predictive of lower rates of sepsis.
CONCLUSIONS: