Details

Autor(en) / Beteiligte

• Hassine, Hana Ben
• Zemni, Ramzi
• Nacef, Imen Ben
• Boumiza, Asma
• Slama, Foued
• Baccouche, Khadija
• Amri, Najla
• Melayah, Sarra
• Shakoor, Zahid
• Almogren, Adel
• Bouajina, Elyes
• Sghiri, Rim

Titel

A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis

Ist Teil von

• Clinical rheumatology, 2019-04, Vol.38 (4), p.1067-1074

Ort / Verlag

London: Springer London

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Objectives This study was aimed to investigate the association of the single nucleotide polymorphism of tumor necrosis factor receptor associated factor 6 (TRAF6), rs540386, with low bone mineral density (BMD) among patients with rheumatoid arthritis (RA). Methods TRAF6 rs540386 genotyping was performed by mutagenically separated PCR in a cohort of 188 (23 men, 165 women, median age, 56.2 years) adult RA patients and 224 age and gender-matched controls. BMD was measured using dual-energy X-ray absorptiometry (DXA) (Lunar Prodigy advance scans, GE Healthcare, USA). Results Among the RA patients, 64 (55 women, 9 men) had low BMD comprising of 57 patients with osteoporosis and 7 with osteopenia. Whereas TRAF6 rs540386 was not associated with RA susceptibility, it was however found to be a risk factor for reduced lumbar spine Z -score in the recessive model (OR = 3.34, 95% CI = (1.01–11.00), p  = 0.038). This association was confirmed further in the multivariate logistic regression analysis taking into account several potential confounding factors (OR = 3.34 (1.01–11.00), p  = 0.048). In addition, mean total femur Z -score was found to be reduced in TT patients when compared to CC + CT patients (− 1.30 ± 1.32 versus − 0.60 ± 1.05, p  = 0.034). No association between TRAF6 rs540386 and local bone damage was observed. Conclusions This study for the first time ever demonstrated an association between a genetic variant of TRAF6 and low BMD among patients with RA. Further investigations are needed to elucidate the exact role of this variant.