Details

Autor(en) / Beteiligte

• Tedder, R.S.
• Shanson, D.C.
• Jeffries, D.J.
• Cheingsong-Popov, R.
• Dalgleish, A.
• Clapham, P.
• Nagy, K.
• Weiss, R.A.

Titel

LOW PREVALENCE IN THE UK OF HTLV-I AND HTLV-II INFECTION IN SUBJECTS WITH AIDS, WITH EXTENDED LYMPHADENOPATHY, AND AT RISK OF AIDS

Ist Teil von

• The Lancet (British edition), 1984-07, Vol.324 (8395), p.125-128

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

1984

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals Complete

Beschreibungen/Notizen

• Antibodies reacting selectively with human T-cell leukaemia virus type I (HTLV-I) were detected in approximately 5% patients with extended lymphadenopathy syndrome (ELAS) and in less than 1% of unselected homosexual patients and drug abusers. None of 22 patients with acquired immunodeficiency syndrome (AIDS) had HTLV-I antibodies and neither did 85 haemophiliacs and 940 blood donors. 3 out of 113 drug addicts had high titres of antibodies to human T-cell leukaemia virus type II (HTLV-II). A T-cell line was derived from 1 of the seropositive ELAS patients. This line was found to be infected with, and releasing, HTLV-I. Infection by HTLV-I and HTLV-II retroviruses thus occurs more frequently in ELAS patients and drug addicts than in the UK population as a whole, but the low prevalence of these infections in ELAS and AIDS patients indicates that these two strains of lymphotropic retroviruses have no aetiological role in ELAS and AIDS.