Details

Autor(en) / Beteiligte

• Lu, Xia
• Nie, Binbin
• zhu, ziwei
• Mi, Hongzhi
• xie, xiaofen
• Li, Xiang
• Hacker, Marcus
• wei, yongxiang
• Zhang, Xiaoli

Titel

18F-FDG PET/CT evaluation of changes on cerebral glucose metabolism in patients with ischemic heart disease and heart failure

Ist Teil von

• The Journal of nuclear medicine (1978), 2018-05, Vol.59, p.227

Ort / Verlag

New York: Society of Nuclear Medicine

Erscheinungsjahr

2018

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Introduction: Recent studies have demonstrated that congestive heart failure (HF) patients have been widely physiologically linked to increased prevalence of a variety of cognitive functional impairments. Using magnetic resonance images (MRI) as an end-point showed reduced cerebral grey matter volume in HF patients. We aimed to evaluate cerebral glucose metabolism (GM) using cerebral 18F-FDG PET/CT in ischemic heart disease patients with HF (HF) and without HF (IHD). Methods: 86 patients (age 57±10y, male 79) with coronary artery disease (SPECT/CT LVEF: 28±15% and PET/CT LVEF: 34±14%) underwent 99mTc-sestamibi SPECT/CT myocardial perfusion imaging, 18F-FDG PET/CT cerebral and myocardial GM imaging. Patients with mental disorders were excluded. Patients were classified into HF group (n = 44) and IHD group (n = 42) by clinical diagnosis. Left ventricular (LV) functional parameters by gated PET/CT and SPECT/CT were analyzed by QGS software. The total brain and cerebellar GM determined by the mean of standardized uptake value (SUVmean) was obtained by QED software and analyzed by statistical parametric mapping (SPM 12.0). Mean target to background ratio (TBR) was calculated by the total brain GM (bSUVmean) divided by cerebellar GM (cSUVmean). Furthermore, the correlation between TBR and age, insulin dose, blood glucose level, LV functional parameters and myocardial viability was analyzed by Spearman correlation analysis. Results: Mean TBR was significantly correlated with LVEF by gated PET (r = 0.246, p<0.05), summed rest score (r = -0.233, p<0.05), summed FDG score (r = -0.303, p<0.01), perfusion-metabolism mismatch score (r =0.246, p<0.05), the extent of myocardial viability (%LV) (r = -0.226, p<0.05), and scar (%LV) (r = -0.284, p<0.01). TBR in patients with HF (1.28±0.13) was significantly lower than that in patients with IHD (1.36±0.14, p<0.01). Moreover, the results of SPM revealed that, in comparison with IHD patients, there was significant reduction in cerebral metabolism in frontal lobes which closely related to compromise attention, memory, and executive function in patients with HF. Conclusions: Cerebral 18F-FDG PET might be used as a surrogate end-point prior to psychological disorder. Research Support: Natural Science Foundation of China(No.81571717, No.81071177, No.81641072)