Details

Autor(en) / Beteiligte

• Kashapov, Ruslan R.
• Bekmukhametova, Alina M.
• Petrov, Konstantin A.
• Nizameev, Irek R.
• Kadirov, Marsil K.
• Zakharova, Lucia Ya

Titel

Supramolecular strategy to construct quantum dot-based sensors for detection of paraoxon

Ist Teil von

• Sensors and actuators. B, Chemical, 2018-11, Vol.273, p.592-599

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• [Display omitted] •A simple quantum dot-based sensor is developed for detection of paraoxon.•This sensor is obtained by using the simple supramolecular method.•The functionality of sensor is tested with blood samples of paraoxon-poisoned rats.•Paraoxon sensing has been performed with low detection limit. The development of advanced tools for sensing specific materials remains an ongoing challenge. Detailed below is a new quantum dot (QD)-based sensor via supramolecular interactions, demonstrating a novel simplicity of design to obtain sensitive QDs while avoiding their covalent cross-linking. A simple label-free and turn-off method for the detection of paraoxon and its degradation products in aqueous media was proposed by using the fluorescent QD/surfactant/cyclodextrin supramolecular system. This nanocomposite was prepared from 3-mercaptopropionic acid-capped CdTe QDs coated with cetyltrimethylammonium bromide (CTAB) through electrostatic self-assembly. Further nanocomposite modification by β-cyclodextrin (β-CD), thanks to hydrophobic interaction between cetyl tails of surfactants and inner cavity of macrocycle contributed to an increase in emission intensity and stability in aqueous solution. The strong fluorescence of CdTe/CTAB/β-CD nanocomposite can be effectively quenched by the addition of paraoxon due to the host–guest complexation between β-CD cavity and paraoxon degradation product. The functionality of the paraoxon sensor was also tested with blood samples of paraoxon-poisoned rats (1/2 × LD50). These fluorescent nanocomposites were obtained by using the simple supramolecular method to coat QDs with surfactant–cyclodextrin shells. This coating strategy potentially offers common method for the functionalization of QDs and avoids time-consuming synthesis procedures.