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With the advent and popularity in peripherally inserted central catheter (PICC) use, reflected in clinical benefits, a growing body of evidence suggested they may also have significant consequences. PICC migration from the optimal position due to unsatisfactory securement may be avoided if stabilization was optimal. Novel securement devices have shown effectiveness; however, each device has had its challenges. There is a recognized need to recommend a securement method that is cost effective, yet provides securement and stabilization as defined. The purpose of this quantitative, causal comparative, descriptive project was to see if a relationship existed between tissue adhesive (TA) applied over the PICC at the insertion site and the exposed visible catheter length (EVL) for adult medical surgical patients at a 280-bed acute care hospital in the southwest United States. Intervention participation included 31 patients (N = 31). Roger’s diffusion of innovation provided the theoretical framework to guide the intervention from application of the collective process to an adoptive behavior. A two-sample t-test and chi-square test was used to analyze the continuous and definite variables. Statistical analyses applied to equate baseline to innovation, encapsulated the basic topographies of the solution and offered a qualitative narrative in a wieldy arrangement. Inferences presented no catheter migrations with a p = .010(FE 0.02), which was statistically significant. This project supported tissue adhesive as a safe, inexpensive, and highly effective alternative to secure and stabilize PICCs. Further studies are recommended to speak to the continued use and the sustainability of tissue adhesive for securement and stabilization of PICCs.