Details

Autor(en) / Beteiligte

• de Oliveira Ferreira, Raíssa
• Guimarães, Abraão Tiago Batista
• Rocha, Thiago Lopes
• de Lima Rodrigues, Aline Sueli
• de Oliveira Mendes, Bruna
• Mesak, Carlos
• Malafaia, Guilherme

Titel

The potential reproductive toxicity of tannery effluent to the estrous cycle and ovarian follicular dynamics of female Swiss mice

Ist Teil von

• Environmental science and pollution research international, 2018-12, Vol.25 (36), p.36355-36367

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Although the toxic effects of tannery effluent (TE) on tanning-industry workers have been reported in many studies, its effects on females’ reproductive system are unknown. We aimed at evaluating the effects of direct contact with TE on the “emotional” status, estrous cycle (during 15 consecutive exposure days), and ovarian follicular dynamics of female Swiss mice at the end of the experiment to broaden the knowledge about the toxicity of this pollutant. The herein adopted exposure protocol simulated tanning-industry workers’ exposure to TE. The test animals were subjected to 45 exposure days, for 1 h a day, 5 days a week (from Monday to Friday). Based on the collected data, female mice exposed to TE recorded high anxiety index in the elevated plus maze test, although we did not observe changes in their estrous cycle. The smaller total and specific number of ovarian follicles (types 1 to 6) and the higher frequency of degenerating follicles (atresic) in female mice exposed to TE marked the folliculogenesis reduction in them. Therefore, our study was the first to provide evidences that the exposure to TE can cause reproduction issues in female mice, as well as the first experimental insight about the impact of unhealthy work activities in tanning industries on women’s reproductive system.