Details

Autor(en) / Beteiligte

• Prunduş, Camelia R
• Ciobanu, Lidia
• Bolboacă, Sorana D
• Tanţău, Marcel
• Matei, Daniela
• Cruciat, Carmen
• Pojoga, Cristina
• Andreica, Vasile

Titel

The association between inflammatory bowel diseases and Helicobater pylori infection: a case-control Romanian study

Ist Teil von

• Human & veterinary medicine, 2018-09, Vol.10 (3), p.137-141

Ort / Verlag

Cluj-Napoca: Bioflux SRL

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Aim: The main objective of this study was to investigate the association between inflammatory bowel disease (IBD) and Helicobacter pylori (Hp) infection, on a Romanian population. A secondary analysis studied the association of previous Hp eradication therapy and the onset of IBD. Methods: A case-control study was conducted with a 1:2 design (age- and gender-matched controls). The study was conducted in an outpatient department in a single center. The participants answered the same questionnaire about previous history of IBD and Hp infectious status, and blood samples were obtained to determine Hp serology. Results: The study included 145 patients known with IBD (73.8% had ulcerative colitis (UC), 26.2% had Crohn's disease (CD)) and 290 age and sex match controls. Hp was positive in 22.4% of IBD patients and 34.2% of controls. The presence of Hp proved a protective factor for IBD as compared to the controls: OR= 0.440 (95%CI: 0.285 to 0.680, p<0.001). The rate of previous Hp eradication therapy in patients with IBD was lower and statistically different from that observed in the control group (5.5% (95%CI: 1.8 to 9.2) and 19% (95%CI: 14.5 to 23.5), respectively, p<0.001). Conclusions: We observed a negative association between Hp infection and IBD. Further prospective studies about the relation between Hp infection and IBD have to take in consideration more variables.