Details

Autor(en) / Beteiligte

• Wang, Liping
• Zhang, Yuecheng
• Li, Fanfan
• Hao, Xinyu
• Zhang, Hong‐Yu
• Zhao, Jiquan

Titel

Direct C−H Trifluoromethylation of Quinoxalin‐2(1H)‐ones under Transition‐Metal‐Free Conditions

Ist Teil von

• Advanced synthesis & catalysis, 2018-10, Vol.360 (20), p.3969-3977

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Disclosed herein is a direct C−H trifluoromethylation of quinoxalin‐2(1H)‐ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3‐trifluoromethylquinoxalin‐2(1H)‐one derivatives in moderate to excellent yields under transition‐metal‐free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition‐metal‐catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones.