Details

Autor(en) / Beteiligte

• Pham, Phuc H.
• Nguyen, Que T. D.
• Tran, Nhu K. Q.
• Nguyen, Vu H. H.
• Doan, Son. H.
• Ha, Hiep Q.
• Truong, Thanh
• Phan, Nam T. S.

Titel

Metal‐Free Synthesis of Furocoumarins: An Approach via Iodine‐Promoted One‐Pot Cyclization between 4‐Hydroxycoumarins and Acetophenones

Ist Teil von

• European journal of organic chemistry, 2018-08, Vol.2018 (32), p.4431-4435

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A transition metal‐free approach was developed to achieve substituted furocoumarins via an iodine‐promoted one‐pot cyclization between 4‐hydroxycoumarins and acetophenones. High yields of furocoumarins were achieved in the presence of NH4OAc as an additive, while neither acidic nor basic additives were effective. The reaction would proceed via a 5‐exo‐tet cyclization but not an O‐alkylation. The fact that commercially available starting materials could be used without the need of a transition metal catalyst could be a significant advantage. An iodine‐mediated one‐pot synthesis of furocoumarins has been developed. The furocoumarins were obtained in high yields in the presence of NH4OAc as an additive, whereas neither acidic nor basic additives were effective.