Details

Autor(en) / Beteiligte

• Yeon, K.Y.
• Kim, S.A.
• Kim, Y.H.
• Lee, M.K.
• Ahn, D.K.
• Kim, H.J.
• Kim, J.S.
• Jung, S.J.
• Oh, S.B.

Titel

Curcumin Produces an Antihyperalgesic Effect via Antagonism of TRPV1

Ist Teil von

• Journal of dental research, 2010-02, Vol.89 (2), p.170-174

Ort / Verlag

Washington, DC: SAGE Publications

Erscheinungsjahr

2010

Quelle

MEDLINE

Beschreibungen/Notizen

• Curcumin has diverse therapeutic effects, such as anti-inflammatory, anti-oxidant, anti-cancer, and antimicrobial activities. The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception. However, very little is known about the effects of curcumin on nociception. In the present study, we investigated whether the anti-nociceptive effects of curcumin are mediated via TRPV1 by using nociceptive behavioral studies and in vitro whole-cell patch-clamp recordings in the trigeminal system. Subcutaneous injection of capsaicin in the vibrissa pad area of rats induced thermal hyperalgesia. Intraperitoneally administered curcumin blocked capsaicin-induced thermal hyperalgesia in a dose-dependent manner. Whereas curcumin reduced capsaicin-induced currents in a dose-dependent manner in both trigeminal ganglion neurons and TRPV1-expressing HEK 293 cells, curcumin did not affect heat-induced TRPV1 currents. Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity.