Details

Autor(en) / Beteiligte

• Xi, Yu-Fei
• Zhou, Le
• Bai, Ming
• Wang, Jie
• Lin, Bin
• Wang, Xiao-Bo
• Huang, Xiao-Xiao
• Song, Shao-Jiang

Titel

N-acylanthranilic acid derivatives with anti-Aß^sub 1–42^ aggregation activity from the leaves of Isatis indigotica fortune

Ist Teil von

• Fitoterapia, 2018-07, Vol.128, p.169

Ort / Verlag

Milan: Elsevier Science Ltd

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Seven new N-acylanthranilic acid derivatives (1–3, 4a/4b, 5a/5b) including two pairs of enantiomers (4a/4b and 5a/5b) were isolated from the leaves of Isatis indigotica Fortune. Their chemical structures were elucidated by extensive spectroscopic data analyses. The absolute configurations of compounds 4a/4b and 5a/5b were determined by comparison of the experimental and calculated ECD spectra. All compounds were tested for their anti-Aβ1–42 aggregation activity. As a result, compounds 1 (72.1%), 2 (79.8%) and 5a (81.8%) showed stronger inhibitory activity than the positive control curcumin (67.0%). By the comparison between 5a (81.8%) and 5b (63.1%), it was found that stereochemical configurations may affect Aβ1–42 aggregation activity, which was discussed through the molecular docking results of compounds 5a and 5b.