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Reye's syndrome developing in an infant on treatment of Kawasaki syndrome
Ist Teil von
Journal of paediatrics and child health, 2005-05, Vol.41 (5‐6), p.303-304
Ort / Verlag
PO Box 378 , Carlton South Victoria 3053 , Australia: Blackwell Science Pty
Erscheinungsjahr
2005
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
: Aspirin is commonly used as an anti‐inflammatory therapy for Kawasaki syndrome. Early initiation with high dose aspirin (80 to >100 mg/kg per day), followed by low‐dose therapy at the afebrile stage, has been often used to reduce morbidity and mortality in coronary complications. We report a 10‐month‐old infant who was diagnosed with Kawasaki syndrome. Sudden onset of poor activity, poor appetite, lethargy, tachycardia, tachypnea, hepatomegaly, increased AST/ALT, coagulopathy and hyperammonemia developed 3 days after the high‐dose aspirin therapy. His histopathological and ultrastructural findings from the liver biopsy were compatible with Reye's syndrome. He recovered completely, and there was no recurrence.