Details

Autor(en) / Beteiligte

• Yoshida, Eri
• Lawn, Murray
• Nagayasu, Takeshi
• Kamada, Kai

Titel

Enhancement of antibacterial effect of quaternary ammonium with inorganic nanosheets against Enterobacter cloacae

Ist Teil von

• Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2018-07, Vol.20 (7), p.1-11, Article 199

Ort / Verlag

Dordrecht: Springer Netherlands

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To suppress nosocomial infections, numerous studies of quaternary ammonium cations (R 4 N + ) to improve the antibiotic properties have been investigated. However, most of them reported developments of novel organic or polymeric materials with R 4 N + . To pioneer antibacterial inorganic materials hybridized with R 4 N + , a colloidal solution of metal oxide nanosheets, which have a small particle size (typically less than 10 nm), is considered to be a suitable option because oxide nanosheets with a negative surface charge strongly interact R 4 N + . Herein, we demonstrate for the first time that the high antibacterial/bactericidal effects of titanate nanosheets (TNS) adsorbing tetramethylammonium (TMA-TNS) or tetrabultylammonium ions (TBA-TNS). Their antibacterial effects against Enterobacter cloacae were evaluated using a colony forming unit (CFU) counting method. The results showed that the synthesized TNS composites had superior antibacterial and bactericidal effects to those of free R 4 N + and TBA-TNS exhibited the strongest effect (69% CFU reduction compared with that of free TBA + and 98% CFU reduction compared with the control) among the samples examined. Dark incubation was employed to ensure that photocatalytic reaction of semiconducting TNS did not contribute to the process. Compared with TiO 2 spherical particles, such high bactericidal effect would be induced by a synergistic function of TBA + and TNS, which physically damages bacteria due to long hydrophobic alkyl chains and an anisotropic nanocrystalline structure with sharp edges, respectively.