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The Lancet infectious diseases, 2004-03, Vol.4 (3), p.136-137
Ort / Verlag
United States: Elsevier Ltd
Erscheinungsjahr
2004
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
RNA extracted from these cells was studied by quantitative RT-PCR and twice showed increased interferon γ message in both paratuberculin and tuberculin-stimulated cells compared with unstimulated cells (induction ratio of 25–100 fold).Since the patient was in chronic abdominal pain and unable to function in daily activities, anti-MAP treatment was offered, consisting of clarith-romycin and rifabutin.Because of the recent published material showing genetic susceptibility to Crohn's disease, we also did genetic testing, targeting documented susceptibility alleles of the NOD2/CARD15 gene (G908R, R702W, and 3020ins).The patient was heterozygous for the G908R substitution and homozygous wild-type for the other alleles.[...]this man has evidence of typically defined Crohn's disease with a Crohn's disease susceptibility mutation, but also has evidence of human MAP disease.