Journal of neurochemistry, 2005-08, Vol.94 (3), p.819-827
2005
Details
- Autor(en) / Beteiligte
- Titel
- Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical‐scavenging activity
- Ist Teil von
- Journal of neurochemistry, 2005-08, Vol.94 (3), p.819-827
- Ort / Verlag
- Oxford, UK: Blackwell Science Ltd
- Erscheinungsjahr
- 2005
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Minocycline is neuroprotective in animal models of a number of acute CNS injuries and neurodegenerative diseases. While anti‐inflammatory and anti‐apoptotic effects of minocycline have been characterized, the molecular basis for the neuroprotective effects of minocycline remains unclear. We report here that minocycline and a number of antioxidant compounds protect mixed neuronal cultures in an oxidative stress assay. To evaluate the role of minocycline's direct antioxidant properties in neuroprotection, we determined potencies for minocycline, other tetracycline antibiotics, and reference antioxidant compounds using a panel of in vitro radical scavenging assays. Data from in vitro rat brain homogenate lipid peroxidation and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging assays show that minocycline, in contrast to tetracycline, is an effective antioxidant with radical scavenging potency similar to vitamin E. Our findings suggest that the direct antioxidant activity of minocycline may contribute to its neuroprotective effects in some cell‐based assays and animal models of neuronal injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-3042eISSN: 1471-4159DOI: 10.1111/j.1471-4159.2005.03219.xTitel-ID: cdi_proquest_journals_206542106
- Format
- –
- Schlagworte
- Animals, Antibiotics, Antioxidants, Antioxidants - pharmacology, Antipyrine - analogs & derivatives, Antipyrine - pharmacology, Benzothiazoles, Biological and medical sciences, Cell Death - drug effects, Cells, Cultured, Cerebral Cortex - cytology, Chromans - pharmacology, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Deoxyribose - metabolism, deoxyribose degradation assay, Dizocilpine Maleate - pharmacology, Dose-Response Relationship, Drug, Drug Interactions, Embryo, Mammalian, Free Radical Scavengers - pharmacology, Free Radicals - pharmacology, Glutamic Acid - pharmacology, Inhibitory Concentration 50, L-Lactate Dehydrogenase - metabolism, Lipid Peroxidation - drug effects, lipid peroxidation assay, Medical sciences, Minocycline - chemistry, Minocycline - pharmacology, mixed neuronal cultures, neurodegenerative diseases, Neurology, Neurons, Neurons - drug effects, Neuropharmacology, Neuroprotective agent, Neuroprotective Agents - pharmacology, Oxidation, Oxidative Stress - drug effects, Oxidative Stress - physiology, Pharmacology. Drug treatments, Phenethylamines - metabolism, radical scavenging assay, Rats, Rats, Sprague-Dawley, Stress, Sulfonic Acids - metabolism, tetracyclines, Vitamin E - pharmacology