Details

Autor(en) / Beteiligte

• Jin, Guofan
• Xiao, Fuyan
• Liu, Ruijiang

Titel

Synthesis and biological evaluation of a new series of ortho-carboranyl biphenyloxime derivatives

Ist Teil von

• BMC chemistry, 2018-06, Vol.12 (1), p.1-7

Ort / Verlag

London: Springer Nature B.V

Erscheinungsjahr

2018

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• (Z,Z’)-1,1′-(4-ortho-Caboranyldimethyl)-bis(2-methoxyphenylethan-1-oxime) intermediate 3 was synthesized by a three-step reaction with a final treatment with base to give a new series of ortho-carboranyl biphenyloxime derivatives (4–8). Compounds 7 and 8 showed high solubility and the in vitro study results revealed high levels of accumulation in HeLa cells with higher cytotoxicity and boron uptake compared to l-boronphenylalanine.