Details

Autor(en) / Beteiligte

• Strugov, Vladimir
• Stadnik, Elena
• Virts, Yulia
• Andreeva, Tatyana
• Zaritskey, Andrey

Titel

Impact of age and comorbidities on the efficacy of FC and FCR regimens in chronic lymphocytic leukemia

Ist Teil von

• Annals of hematology, 2018-11, Vol.97 (11), p.2153-2161

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2018

Quelle

SpringerNature Journals

Beschreibungen/Notizen

• CLL is an aging-associated neoplasm with median age at diagnosis > 65 years. Little is known about safety and efficacy of FC/FCR regimens in elderly CLL patients with multiple comorbidities. We retrospectively revised medical records of 90 patients treated with FC/FCR regimens in our clinic. Data on demographic and biological characteristics, comorbidities, response to therapy, and treatment-associated adverse events were analyzed. Compared to FC, FCR yielded higher rates of OR (93.6 vs. 81.4%, p  = .109) and CR (72.3 vs. 46.5%, p  = .018). This translated in longer EFS (median 52 vs. 19 months, p  = <.001) and OS (median 89 vs. 45 months, p  = .001). Elderly patients (≥ 65 years) had more comorbidities and higher median CIRS-G score (7 vs. 4, p  < .001). However, no association was found between CIRS-G score and survival. Decreased renal function was associated with dismal prognosis in patients treated with FCR.