Details

Autor(en) / Beteiligte

• Pettinari, Riccardo
• Marchetti, Fabio
• Petrini, Agnese
• Pettinari, Claudio
• Lupidi, Giulio
• Fernández, Belén
• Diéguez, Antonio Rodríguez
• Santoni, Giorgio
• Nabissi, Massimo

Titel

Ruthenium(II)-arene complexes with dibenzoylmethane induce apoptotic cell death in multiple myeloma cell lines

Ist Teil von

• Inorganica Chimica Acta, 2017-01, Vol.454, p.139-148

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Ru(II)-arene dibenzoylmethanide complexes bind to calf thymus DNA through intercalative/electrostatic interactions with more affinity for DNA minor groove and display good cytotoxic and pro-apoptotic effect toward U266 and RPMI human multiple myeloma cell lines. [Display omitted] •Synthesis of Ru(II)-arene dibenzoylmethane complexes.•Analytical, spectral and X-ray characterization.•Antitumor activity in vitro against U266 and RPMI human multiple myeloma cell lines.•DNA interaction studies.•Protein binding studies. A series of ruthenium(II) arene complexes (arene=p-cymene, hexamethylbenzene and benzene) containing dibenzoylmethane ligand (DBMH) of formula [(arene)Ru(DBM)Cl] and their ionic derivatives bearing PTA (1,3,5-triaza-7-phosphaadamantane), of formula [(arene)Ru(DBM)(PTA)]X (X=PF6- or SO3CF3-) have been synthesized and fully characterized. The solid-state structures of five complexes have been determined by single-crystal X-ray diffraction. These ruthenium materials exhibit intense photoluminescence emission at room temperature in the solid state. All complexes effectively bind to calf thymus DNA through intercalative/electrostatic interactions with more affinity for DNA minor groove. Finally, the antitumor activity of both ligand and complexes was evaluated against the U266 and RPMI human multiple myeloma cell lines, and some of them showed a cytotoxic and pro-apoptotic effect toward both cell lines.