Details

Autor(en) / Beteiligte

• Bushnell, David
• Menda, Yusuf
• Madsen, Mark
• O'Dorisio, Thomas
• Carlisle, Thomas
• Zehr, Pamela
• Ponto, Laura
• Karwal, Mark
• Parker, Stan
• Ponto, James
• Connolly, Mary
• Hakim Bouterfa

Titel

Assessment of Hepatic Toxicity from Treatment with ^sup 90^Y-SMT 487 (OctreoTher(TM)) in Patients with Diffuse Somatostatin Receptor Positive Liver Metastases

Ist Teil von

• Cancer biotherapy & radiopharmaceuticals, 2003-08, Vol.18 (4), p.581

Ort / Verlag

New Rochelle: Mary Ann Liebert, Inc

Erscheinungsjahr

2003

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The purpose of this study was to determine whether there is evidence for hepatocellular radiation injury following treatment with (90)Y-SMT487 ((90)Y-DOTA-tyr3-octreotide, OctreoTher(TM)) in patients with extensive liver metastases from neuroendocrine tumors. Patients reported in this study participated in a Phase II trial of efficacy and safety of (90)Y-SMT487. The trial design called for three treatment cycles of 120 mCi each (4400 MBq) of (90)Y-SMT487. (111)In-pentetreotide SPECT images were used to determine the extent of liver metastases. Serum AST, ALT, and alkaline phosphatase levels were obtained at baseline and following each cycle of therapy. Least squares fit was applied to the serial liver enzyme measurements in patients with extensive liver metastases. Post-therapy liver enzyme measurements were also evaluated using WHO common toxicity criteria. Repeated-measures ANOVA and paired t-test were applied to the serial enzyme measures. There were 21 subjects. Fifteen of these had hepatic metastases with 12 demonstrating extensive (defined as 25% or more) liver involvement. In only 4 of these 15 did any of the three enzyme levels increase in WHO toxicity grade from baseline to final follow-up. We conclude that patients with diffuse SSTR positive hepatic metastases can be treated with a cumulative administered activity of 360 mCi (90)Y-SMT487 with only a small chance of developing mild acute or subacute hepatic radiation injury.