Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites
Ist Teil von
BMJ (Online), 1999-05, Vol.318 (7196), p.1451
Auflage
International edition
Ort / Verlag
England: BMJ Publishing Group
Erscheinungsjahr
1999
Quelle
Applied Social Sciences Index & Abstracts (ASSIA)
Beschreibungen/Notizen
To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom.
Sequential randomised, double blind, placebo controlled trial.
Public hospital in a venom research institute, São Paulo, Brazil.
101 patients requiring antivenom treatment after being bitten by bothrops snakes.
Intramuscular injection of promethazine (25 mg for adults and 0.5/kg for children) or placebo given 15-20 min before starting intravenous infusion of antivenom.
Incidence and severity of anaphylactic reactions occurring within 24 hours after antivenom.
Reactions occurred in 12 of 49 patients treated with promethazine (24%) and in 13 of 52 given placebo (25%); most were mild or moderate. Continuous sequential analysis indicated that the study could be interrupted at the 22nd untied pair, without preference for promethazine or placebo.
Prophylaxis with promethazine does not prevent early reactions. Patients should be observed carefully during antivenom infusion and the subsequent few hours.