Details

Autor(en) / Beteiligte

• Antons, J.
• Marascio, M. G. M.
• Nohava, J.
• Martin, R.
• Applegate, L. A.
• Bourban, P. E.
• Pioletti, D. P.

Titel

Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Ist Teil von

• Journal of materials science. Materials in medicine, 2018-05, Vol.29 (5), p.57-8, Article 57

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2018

Quelle

SpringerLink Journals

Beschreibungen/Notizen

• Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.