Details

Autor(en) / Beteiligte

• Krishnan, Mohanraj
• Major, Tanya J.
• Topless, Ruth K.
• Dewes, Ofa
• Yu, Lennex
• Thompson, John M. D.
• McCowan, Lesley
• de Zoysa, Janak
• Stamp, Lisa K.
• Dalbeth, Nicola
• Harré Hindmarsh, Jennie
• Rapana, Nuku
• Deka, Ranjan
• Eng, Winston W. H.
• Weeks, Daniel E.
• Minster, Ryan L.
• McGarvey, Stephen T.
• Viali, Satupa’itea
• Naseri, Take
• Sefuiva Reupena, Muagututi’a
• Wilcox, Phillip
• Grattan, David
• Shepherd, Peter R.
• Shelling, Andrew N.
• Murphy, Rinki
• Merriman, Tony R.

Titel

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand

Ist Teil von

• Diabetologia, 2018-07, Vol.61 (7), p.1603-1613

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2018

Quelle

SpringerLink

Beschreibungen/Notizen

• Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations of Samoa and American Samoa. Our aim was to test rs373863828 for associations with BMI and the odds of type 2 diabetes, gout and chronic kidney disease (CKD) in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand. Methods Linear and logistic regression models were used to analyse the association of the A allele of CREBRF rs373863828 with BMI, log-transformed BMI, waist circumference, type 2 diabetes, gout and CKD in 2286 adults. The primary analyses were adjusted for age, sex, the first four genome-wide principal components and (where appropriate) BMI, waist circumference and type 2 diabetes. The primary analysis was conducted in ancestrally defined groups and association effects were combined using meta-analysis. Results For the A allele of rs373863828, the effect size was 0.038 (95% CI 0.022, 0.055, p  = 4.8 × 10 −6 ) for log-transformed BMI, with OR 0.59 (95% CI 0.47, 0.73, p  = 1.9 × 10 −6 ) for type 2 diabetes. There was no evidence for an association of genotype with variance in BMI ( p  = 0.13), and nor was there evidence for associations with serum urate (β = 0.012 mmol/l, p corrected  = 0.10), gout (OR 1.00, p  = 0.98) or CKD (OR 0.91, p  = 0.59). Conclusions/interpretation Our results in New Zealand Polynesian adults replicate, with very similar effect sizes, the association of the A allele of rs373863828 with higher BMI but lower odds of type 2 diabetes among Samoan adults living in Samoa and American Samoa.