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Impact of Zinc Deficiency on Vibrio Cholerae Enterotoxin-stimulated Water and Electrolyte Transport in Animal Model
Ist Teil von
Journal of health, population and nutrition, 2006-03, Vol.24 (1), p.42-47
Ort / Verlag
Bangladesh: ICDDR,B: Centre for Health and Population Research
Erscheinungsjahr
2006
Quelle
Applied Social Sciences Index & Abstracts (ASSIA)
Beschreibungen/Notizen
The effect of zinc deficiency on the function of the intestine to
absorb water and electrolytes was studied in animal models, stimulated
by Vibrio cholerae enterotoxin. Sprague-Dawley rats, used in the
study, were divided into four groups: Zinc-deficient, ad libitum
zinc-fed control, zinc weight-matched control, and zinc-deficient
acutely-repleted. 14C-labelled polyethylene glycol solution was used
for measuring the absorption capacity of the small intestine.
Significantly lower absorption of water and sodium per cm of the
intestine was observed in the zinc-deficient animals compared to the ad
libitum zinc-fed control animals (p<0.01). An improved absorption
capacity was equally observed in the zinc-deficient acutely-repleted
animals and ad libitum zinc-fed control group. The zinc-deficient
animals showed four times greater cholera toxin-induced net secretions
of water and sodium compared to the ad libitum zinc-fed group
(p<0.01), while a 40% reduction was observed in the zinc-deficient
acutely-repleted group. The results suggest that zinc deficiency is
associated with reduced absorption of water and electrolytes and
increased secretion of the same stimulated by cholera toxin.