Details

Autor(en) / Beteiligte

• Nayal, Onkar S.
• Thakur, Maheshwar S.
• Kumar, Manoranjan
• Shaifali
• Upadhyay, Rahul
• Maurya, Sushil K.

Titel

Sustainable and Efficient CuI‐NPs‐Catalyzed Cross‐Coupling Approach for the Synthesis of Tertiary 3‐Aminopropenoates, Triazoles, and Ciprofloxacin

Ist Teil von

• Asian journal of organic chemistry, 2018-04, Vol.7 (4), p.776-780

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• The unique properties of metal nanoparticles have attracted significant attention from synthetic chemists, notably for application in heterogeneous catalysis. Herein, we report a highly efficient, sustainable, and atom‐economical approach for the synthesis of tertiary 3‐aminopropenoates from alkynes and secondary amines by using heterogeneous copper(I) iodide nanoparticles (CuI NPs) as a catalyst. The broad utility of this strategy is demonstrated by the synthesis of a wide range of tertiary 3‐aminopropenoates. The value of this transformation has been highlighted by the synthesis of biologically active ciprofloxacin and its derivatives on a gram scale. This method was also applied to the synthesis of 1,4‐disubstituted 1,2,3‐triazoles. CuI NP catalysis: A highly efficient, sustainable, and atom‐economical synthesis of tertiary 3‐aminopropenoates from alkynes and secondary amines has been developed by using heterogeneous copper(I) iodide nanoparticles (CuI NPs) as a catalyst.