Details

Autor(en) / Beteiligte

• Miao, Zhao‐Hua
• Lv, Lan‐Xiang
• Li, Kai
• Liu, Pei‐Ying
• Li, Zhenglin
• Yang, Huanjie
• Zhao, Qingliang
• Chang, Manli
• Zhen, Liang
• Xu, Cheng‐Yan

Titel

Liquid Exfoliation of Colloidal Rhenium Disulfide Nanosheets as a Multifunctional Theranostic Agent for In Vivo Photoacoustic/CT Imaging and Photothermal Therapy

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2018-04, Vol.14 (14), p.e1703789-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Near‐infrared light‐mediated theranostic agents with superior tissue penetration and minimal invasion have captivated researchers in cancer research in the past decade. Herein, a probe sonication‐assisted liquid exfoliation approach for scalable and continual synthesis of colloidal rhenium disulfide nanosheets, which is further explored as theranostic agents for cancer diagnosis and therapy, is reported. Due to high‐Z element of Re (Z = 75) and significant photoacoustic effect, the obtained PVP‐capped ReS2 nanosheets are evaluated as bimodality contrast agents for computed tomography and photoacoustic imaging. In addition, utilizing the strong near‐infrared absorption and ultrahigh photothermal conversion efficiency (79.2%), ReS2 nanosheets could also serve as therapeutic agents for photothermal ablation of tumors with a tumor elimination rate up to 100%. Importantly, ReS2 nanosheets show no obvious toxicity based on the cytotoxicity assay, serum biochemistry, and histological analysis. This work highlights the potentials of ReS2 nanosheets as a single‐component theranostic nanoplatform for bioimaging and antitumor therapy. Rhenium disulfide nanosheets, a typical two‐dimensional layered transition metal dichalcogenide prepared by a probe sonication‐assisted liquid exfoliation approach, were explored as theranostic agents for computed tomography and photoacoustic imaging‐guided photothermal therapy.