Details

Autor(en) / Beteiligte

• Shekhar, B.
• Vasantha, P.
• Sathish Kumar, B.
• Anantha Lakshmi, P.V.

Titel

Multispectroscopic DNA interaction and Docking studies

Ist Teil von

• Applied organometallic chemistry, 2018-04, Vol.32 (4), p.n/a

Ort / Verlag

Chichester: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Two new water soluble oxovanadium(IV) complexes with formulae Na[VO(his)(met)SO4] (1) and Na[VO(gly)(met)SO4] (2), (gly=glycine his=histidine, and met=metformin) were synthesized and characterized by LCMS, UV‐Visible absorption, infrared spectra, magnetic moment, elemental analysis, thermal analysis and electronic spectral studies. The metal center was found in an octahedral geometry. DNA binding interaction of these complexes with CT DNA has been explored by UV‐Visible absorption, fluorescence, viscosity measurements and cleavage studies. Finally the binding of the complexes with CT‐DNA could be surface binding, mainly in the groove binding. The complexes were docked in to B‐DNA sequence, 5’(D*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)‐3’ retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software. Multispectroscopic DNA interaction studies suggest that the two water soluble Ternary Oxovanadium(IV)‐Metformin‐Glycine/Histidine complexes bind to DNA via groove binding. Molecular docking with B‐DNA indicates that both the compounds bound within the binding site pocket of metformin similar binding pattern with one of the binding site (DG19) nucleotide residue.