Details

Autor(en) / Beteiligte

• Jiang, Ru-Jian
• Yan, Shun-Jie
• Tian, Li-Mei
• Xu, Shi-Ai
• Xin, Zhi-Rong
• Luan, Shi-Fang
• Yin, Jing-Hua
• Ren, Lu-Quan
• Zhao, Jie

Titel

A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks

Ist Teil von

• Chinese journal of polymer science, 2018-05, Vol.36 (5), p.576-583

Ort / Verlag

Beijing: Chinese Chemical Society and Institute of Chemistry, CAS

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA (eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes (deoxyribonuclease), here we report a novel antibacterial surface by employing cerium (Ce(IV)) ion to mimic the DNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid (TA) works as an essential scaffold and Ce(IV) ion acts as both a cross-linker and a destructor of eDNA. The Ce(IV)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(III)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections.