Details

Autor(en) / Beteiligte

• Slebos, Robbert J C
• Lee, Mann H
• Plunkett, Beverly S
• Kessis, Theodore D

Titel

P53-dependent G(1) arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1994-06, Vol.91 (12), p.5320

Ort / Verlag

Washington: National Academy of Sciences

Erscheinungsjahr

1994

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The cell cycle regulatory tumor suppressor protein p53 and pRB are targeted for inactivation by several tumor viruses, including the high-risk types of human papillomaviruses (HPVs) via interactions of the HPV E6 and E7 oncoproteins with p53 and pRB, respectively. A possible role for pRB in the p53-mediated DNA damage response was investigated.