Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (20), p.10942
2000
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Details
- Autor(en) / Beteiligte
- Titel
- A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromsome 5 by the Consortium on Asthma Genetics (COAG)
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (20), p.10942
- Ort / Verlag
- Washington: National Academy of Sciences
- Erscheinungsjahr
- 2000
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds(lod) = 2.61 near IL-4], but not evidence for atopy.