Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1723-1728
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Loss of WAVE-1 Causes Sensorimotor Retardation and Reduced Learning and Memory in Mice
- Ist Teil von
- Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1723-1728
- Ort / Verlag
- United States: National Academy of Sciences
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Scar/WAVE family of scaffolding proteins organize molecular networks that relay signals from the GTPase Rac to the actin cytoskeleton. The WAVE-1 isoform is a brain-specific protein expressed in variety of areas including the regions of the hippocampus and the Purkinje cells of the cerebellum. Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory. These sensorimotor and cognitive deficits are analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP, a component of the WAVE-1 signaling network. Thus WAVE-1 is required for normal neural functioning.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0027-8424eISSN: 1091-6490DOI: 10.1073/pnas.0438033100Titel-ID: cdi_proquest_journals_201339603
- Format
- –
- Schlagworte
- Animals, Antibodies, Biological Sciences, Blotting, Northern, Blotting, Southern, Chromosomes, Artificial, Bacterial, Cloning, Molecular, DNA, Exons, Genotypes, Homologous recombination, Immunohistochemistry, In Situ Hybridization, Knockout mice, Learning, Mazes, Memory, Mice, Mice, Inbred C57BL, Mice, Knockout, Microfilament Proteins - genetics, Microfilament Proteins - physiology, Motor ability, Motor Activity - genetics, Polymerase Chain Reaction, Purkinje cells, Rodents, Wiskott-Aldrich Syndrome Protein Family