Archives of environmental & occupational health, 2005-01, Vol.60 (1), p.17-23
2005
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- Autor(en) / Beteiligte
- Titel
- Genetic Influences on the Retention of Inorganic Mercury
- Ist Teil von
- Archives of environmental & occupational health, 2005-01, Vol.60 (1), p.17-23
- Ort / Verlag
- United States: Heldref
- Erscheinungsjahr
- 2005
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of the GCLM-588T allele was associated with increased blood, plasma and urine mercury levels. These results indicate that genotypes with decreased GSH availability for mercury conjugation affect the metabolism of inorganic mercury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1933-8244eISSN: 2154-4700DOI: 10.3200/AEOH.60.1.17-23Titel-ID: cdi_proquest_journals_201146331
- Format
- –
- Schlagworte
- Adolescent, Adult, adverse effects, Aged, Air Pollutants, Air Pollutants, Occupational - blood, Air Pollutants, Occupational - toxicity, Air Pollutants, Occupational - urine, amalgam, Arbetsmedicin och miljömedicin, blood, Ecuador, Environmental Health and Occupational Health, gene-environment interaction, Genetic, genetics, Genotype, Glutamate-Cysteine Ligase, Glutamate-Cysteine Ligase - genetics, Glutamate-Cysteine Ligase - metabolism, glutamyl-cysteine ligase, Glutathione Transferase, Glutathione Transferase - genetics, Glutathione Transferase - metabolism, Gold, Health Sciences, Humans, Hälsovetenskap, Male, MEDICAL AND HEALTH SCIENCES, MEDICIN OCH HÄLSOVETENSKAP, Mercury, Mercury - blood, Mercury - toxicity, Mercury - urine, metabolism, Middle Aged, Mining, Non-U.S. Gov't, Occupational, Occupational Exposure, Occupational Exposure - adverse effects, Occupational: blood, Occupational: toxicity, Occupational: urine, Polymorphism, Polymorphism, Genetic, polymorphisms, Research Support, toxicity, urine