Details

Autor(en) / Beteiligte

• Mann, D. R.
• Bhat, G. K.
• Stah, C. D.
• Pohl, C. R.
• Plant, T. M.

Titel

Induction of a Hypothyroid State During Juvenile Development Delays Pubertal Reactivation of the Neuroendocrine System Governing Luteinising Hormone Secretion in the Male Rhesus Monkey (Macaca mulatta)

Ist Teil von

• Journal of neuroendocrinology, 2006-09, Vol.18 (9), p.662-671

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2006

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• The present study aimed to determine the influence of thyroid status on the timing of the pubertal resurgence in gonadotrophin‐releasing hormone pulse generator activity [tracked by circulating luteinising hormone (LH) levels] in male rhesus monkeys. Six juvenile monkeys were orchidectomised and then treated with the antithyroid drug, methimazole, from 15–19 months until 36 months of age, at which time thyroxine (T4) replacement was initiated. Four additional agonadal monkeys served as controls. Blood samples were drawn weekly for hormonal assessments. Body weight, crown–rump length and bone age were monitored at regular intervals. By 8 weeks of methimazole treatment, plasma T4 had fallen sharply, and the decline was associated with a plasma thyroid‐stimulating hormone increase. In controls, plasma LH levels remained undetectable until the pubertal rise occurred at 29.3 ± 0.2 months of age. This developmental event occurred in only half of the methimazole‐treated animals before 36 months of age when T4 replacement was initiated. The hypothyroid state was associated with a profound arrest of growth and bone maturation, but increased body mass indices and plasma leptin levels. T4 replacement in methimazole‐treated monkeys was associated with the pubertal rise in LH in the remaining three animals and accelerated somatic development in all six animals. Although pubertal resurgence in LH secretion occurred at a later chronological age in methimazole‐treated animals compared to controls, bone age, crown–rump length and body weight at that time did not differ between groups. There were no long‐term differences in plasma prolactin between groups. We conclude that juvenile hypothyroidism in male primates causes a marked delay in the pubertal resurgence of LH secretion, probably occasioned at the hypothalamic level. Whether this effect is meditated by an action of thyroid hormone directly on the hypothalamus or indirectly as a result of the concomitant deficit in somatic development remains to be determined.