Details

Autor(en) / Beteiligte

• Cheng, Yan
• Xiang, Jia‐Chen
• Wang, Zi‐Xuan
• Ma, Jin‐Tian
• Wang, Miao
• Tang, Bo‐Cheng
• Wu, Yan‐Dong
• Zhu, Yan‐Ping
• Wu, An‐Xin

Titel

Dimerization of Phenylalanine: An Approach to Thiazoles and Oxazoles Involved S/O‐Insertion

Ist Teil von

• Advanced synthesis & catalysis, 2018-02, Vol.360 (3), p.550-555

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library All Journals

Beschreibungen/Notizen

• We herein describe the development of a dimerization procedure for amino acids to prepare 2,5‐disubstituted thiazoles and oxazoles in the presence of Na2S⋅9H2O and H2O, respectively. These approaches enabled the direct formation of five‐membered ring systems bearing two different heteroatoms from two amino acid units. Mechanically, decarboxylation, deamination, S/O insertion, cyclization and gradient oxidation processes were involved in the oligomer formation.