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Chimeric cells of maternal origin in juvenile idiopathic inflammatory myopathies
Ist Teil von
The Lancet (British edition), 2000-12, Vol.356 (9248), p.2155-2156
Ort / Verlag
London: Elsevier Ltd
Erscheinungsjahr
2000
Quelle
Access via ScienceDirect (Elsevier)
Beschreibungen/Notizen
We identified maternal microchimerism by fluorescence in-situ hybridisation in magnetically-separated CD4 or CD8 peripheral blood cells of eight of nine male patients with juvenile idiopathic inflammatory myopathy, compared with two of nine healthy male controls. We also found maternal microchimerism in inflammatory lesions (one skin sample and nine muscle biopsy samples) of all ten patients examined, compared with two of ten biopsy samples from patients with other muscle disorders. These results suggest that maternal cells may be involved in the pathogenesis of juvenile idiopathic inflammatory myopathy.