Details

Autor(en) / Beteiligte

• Ha, Yuan
• Yang, Jie
• Tao, Fei
• Wu, Qian
• Song, Yunjia
• Wang, Haorong
• Zhang, Xu
• Yang, Peng

Titel

Phase‐Transited Lysozyme as a Universal Route to Bioactive Hydroxyapatite Crystalline Film

Ist Teil von

• Advanced functional materials, 2018-01, Vol.28 (4), p.n/a

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• A key factor for successful design of bioactive complex, organic–inorganic hybrid biomaterials is the facilitation and control of adhesion at interfaces, as many current synthetic biomaterials are inert, lacking interfacial bioactivity. In this regard, the development of a simple, unified way to biofunctionalize diverse organic and inorganic materials toward biomineralization remains a critical challenge. In this report, a universal biomimetic mineralization route that can be applied to virtually any type and morphology of scaffold materials is provided to induce nucleation and growth of hydroxyapatite (HAp) crystals based on phase‐transited lysozyme (PTL) coating. Surface‐anchored abundant functional groups in the PTL enrich the interface with strongly bonded calcium ions, facilitating the formation of HAp crystals in simulated body fluid with the morphology and alignment being similar to that observed in natural HAp in mineralized tissues. By the adhesion of amyloid contained in the PTL, such protein assembly could readily integrate HAp on ceramics, metals, semiconductors, and synthetic polymers irrespective of their size and morphology, with robust bonding stability and corresponding ultralow wear extent under normal bone pressure. This strategy successfully improves the in vivo osteoconductivity of Ti‐based implant, underpinning the expectation for such biomaterial in future biointerface and tissue engineering. A universal biomimetic mineralization route is provided to induce crystallization formation of hydroxyapatite (HAp) based on phase‐transited lysozyme nanofilm as a template. HAp as a functional biomaterial can then be applied to virtually any type and morphology of scaffold material. This universal‐surface biomimetic mineralization can be an innovative foundation for future tissue engineering.