Details

Autor(en) / Beteiligte

• Assi, Hazem I.
• Kamphorst, Alice O.
• Moukalled, Nour M.
• Ramalingam, Suresh S.

Titel

Immune checkpoint inhibitors in advanced non–small cell lung cancer

Ist Teil von

• Cancer, 2018-01, Vol.124 (2), p.248-261

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The emergence of immune checkpoint inhibitors for the treatment of cancer has led to major changes to the therapeutic landscape of lung cancer. Improvements in overall survival relative to standard chemotherapy have been observed in the first‐line and second‐line therapy settings for patients with advanced non–small cell lung cancer (NSCLC) who are treated with immune checkpoint inhibitors. Consequently, every patient with advanced‐stage NSCLC is now a candidate for immune checkpoint inhibitor therapy. However, it is clear that the benefit from therapy is not universal, and identification of biomarkers to select therapy has assumed importance. In addition to programmed cell death receptor ligand 1 expression, both tissue‐based and blood‐based markers are under evaluation to select patients. In an era of increasing costs of care and potential for toxicities related to immune checkpoint inhibition, proper patient selection is critical to the optimal use of this new class of agents. In addition, development of novel combination approaches has also emerged as an important way to improve the efficacy of immune checkpoint inhibition. Studies in earlier stages of NSCLC are already underway with the hope of improving the cure rate. In this article, the authors review the current landscape of immune checkpoint inhibitors in the treatment of advanced NSCLC. Cancer 2018;124:248‐61. © 2017 American Cancer Society. Immunotherapy has emerged as an important therapeutic option for patients with advanced‐stage non–small cell lung cancer. The definition and use of biomarkers to identify patients who are more likely to benefit from immunotherapeutic agents remain fundamental issues and will lead to personalized treatment approaches.