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Cyclophosphamide and antithymocyte globulin as a conditioning regimen for allogeneic marrow transplantation in patients with aplastic anaemia: a long‐term follow‐up
Ist Teil von
British journal of haematology, 2005-09, Vol.130 (5), p.747-751
Ort / Verlag
Oxford, UK: Blackwell Science Ltd
Erscheinungsjahr
2005
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Summary
A total of 81 severe aplastic anaemia patients, aged 2–63 years, received human leucocyte antigen‐matched related marrow grafts after cyclophosphamide + antithymocyte globulin followed by postgrafting methotrexate + ciclosporin. Median follow‐up was 9·2 years. Ninety‐six per cent of patients had sustained engraftment, 24% developed acute graft‐versus‐host disease (GVHD), grade II in all but two patients, and 26% developed chronic GVHD; all surviving patients eventually responded to immunosuppressive therapy. Six patients developed cancer: one fatal lymphoma and five carcinomas (all five patients are now free of cancer). Survival was 88%. The regimen appeared well tolerated and effective in heavily pretreated patients with aplastic anaemia.