Details

Autor(en) / Beteiligte

• Bury, Alexander G.
• Pyle, Angela
• Elson, Joanna L.
• Greaves, Laura
• Morris, Christopher M.
• Hudson, Gavin
• Pienaar, Ilse S.

Titel

Mitochondrial DNA changes in pedunculopontine cholinergic neurons in Parkinson disease

Ist Teil von

• Annals of neurology, 2017-12, Vol.82 (6), p.1016-1021

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• In Parkinson disease (PD), mitochondrial dysfunction associates with nigral dopaminergic neuronal loss. Cholinergic neuronal loss co‐occurs, particularly within a brainstem structure, the pedunculopontine nucleus (PPN). We isolated single cholinergic neurons from postmortem PPNs of aged controls and PD patients. Mitochondrial DNA (mtDNA) copy number and mtDNA deletions were increased significantly in PD patients compared to controls. Furthermore, compared to controls the PD patients had significantly more PPN cholinergic neurons containing mtDNA deletion levels exceeding 60%, a level associated with deleterious effects on oxidative phosphorylation. The current results differ from studies reporting mtDNA depletion in nigral dopaminergic neurons of PD patients. Ann Neurol 2017;82:1016–1021