Details

Autor(en) / Beteiligte

• Han, Sang Hoon
• Mishra, Neeraj Kumar
• Jeon, Mijin
• Kim, Saegun
• Kim, Hyung Sik
• Jung, Seung‐Young
• Jung, Young Hoon
• Ku, Jin‐Mo
• Kim, In Su

Titel

Rhodium(III)‐Catalyzed Diastereoselective Synthesis of 1‐Aminoindanes via C−H Activation

Ist Teil von

• Advanced synthesis & catalysis, 2017-11, Vol.359 (22), p.3900-3904

Ort / Verlag

Heidelberg: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The rhodium(III)‐catalyzed cross‐coupling reaction between N‐sulfonyl aldimines and various olefins such as maleimides, fumarates, maleates, α,β‐unsaturated ketones, acrylate and nitroalkenes is described. This transformation efficiently leads to the diastereoselective synthesis of pharmacologically privileged 1‐aminoindane derivatives via the C−H alkylation followed by subsequent intramolecular cyclization. Notably, single diastereomers in all cases were observed, and the relative stereochemistry of products was confirmed by the X‐ray crystallographic data.